PITCR2654
TCR V beta 12 Monoclonal Antibody (S511), FITC, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PITCR2654-Each-of-1 | In Stock | ₹ 50,285.00 |
PITCR2654 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,285.00
GST (18%): ₹ 9,051.30
Total Price: ₹ 59,336.30
Antigen
TCR V beta 12
Classification
Monoclonal
Concentration
0.15 mg/mL
Formulation
PBS with 0.5% BSA and 0.1% sodium azide
Gene Accession No.
P04435
Gene Symbols
TRB
Immunogen
Human TCR V beta 12
Quantity
200 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, T-Cell Activation
Clone
S511
Conjugate
FITC
Gene
TRB
Gene Alias
T cell receptor beta chain; T cell receptor beta locus; TCRB; TCRbeta; Tib; TRB; TRB@
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
6957
Content And Storage
4° C, store in dark
Form
Liquid
Related Products
Description
- TCR2654 targets TCR V beta 12 in FACS, IHC(F), IP, and TCA applications and shows reactivity with Human samples
- The TCR2654 immunogen is human TCR V beta 12
- The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response
- TCR recognition of self-peptides has been linked to autoimmune disease
- Mutant self-peptides have been associated with tumors
- Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome
- Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)
- The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5)
- T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP)
- A small number of T cells lack both CD4 and CD8 (double negative, DN)
- Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders
- Gamma-delta T cells are primarily found within the epithelium
- They show less TCR diversity and recognize antigens differently than alpha-beta T cells
- Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.