366978

5-Fluoroisatin

98%

Manufacturer: Sigma Aldrich

CAS Number: 443-69-6

Synonym(S): 5-Fluoro-2,3-indoledione, NSC 39161

Select a Size

Pack Size SKU Availability Price
5 G 366978-5-G In Stock ₹ 5,228.48

366978 - 5 G

₹ 5,228.48

In Stock

Quantity

1

Base Price: ₹ 5,228.48

GST (18%): ₹ 941.126

Total Price: ₹ 6,169.606

Quality Level

100

Assay

98%

mp

224-227 °C (lit.)

SMILES string

Fc1ccc2NC(=O)C(=O)c2c1

InChI

1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)

InChI key

GKODDAXOSGGARJ-UHFFFAOYSA-N

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Description

  • General description: 5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).[1]
  • Application: 5-Fluoroisatin may be used:as reaction-based probe for live-cell detection of peroxynitrite by 19F magnetic resonance spectroscopy[2]in non-invasive detection of peroxynitrite (ONOO(-)) formation in living lung epithelial cells stimulated with interferon-γ (IFN-γ)[2]in the synthesis of bis-Schiff bases, via condensation with aromatic primary bis-amines in water suspension medium without using any organic solvent or acid catalyst[3]in the synthesis of 3-acetonyl-5-fluoro-3-hydroxyoxindole[4]

SAFETY INFORMATION

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves