49-200-210MG
MilliporeSigma™ Calbiochem™ NOX1 Inhibitor, ML171
Manufacturer: MilliporeSigma™
CAS Number: 6631-94-3
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 49-200-210MG-Each-of-1 | In Stock | ₹ 10,963.91 |
49-200-210MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 10,963.91
GST (18%): ₹ 1,973.504
Total Price: ₹ 12,937.414
Color
Dark Yellow-orange
Molecular Formula
C14H11NOS
Quantity
10 mg
CAS
6631-94-3
Form
Powder
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Selleck Chemical LLC 2-Acetylphenothiazine (ML171) 25mg 6631-94-3 2-APT | -- | ₹ 10,359.60 | ||
Medchemexpress LLC HY-12805 100mg Medchemexpress, ML171 CAS:6631-94-3 Purity:>98% | -- | ₹ 3,284.10 | ||
ML171 | -- | ₹ 3,916.00 - ₹ 43,343.00 |
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Description
- A highly selective, cell-permeable, and reversible 2-acetylphenothiazine that is shown to inhibit NADPH Oxidase-1 (Nox1) (IC 50 = 0.129μM, and 0.25μM) in human HT29 and HEK293 cell-based assays, respectively
- Unlike most other currently used Nox inhibitors, it only has marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms (IC 50 = 5μM, 3μM and 5μM for Nox2, Nox3, and Nox4, respectively) and xanthine oxidase, XO, (IC 50 = 5.5μM) in HEK293 cell-based assays
- It is also shown to block Nox1-dependent ROS generation in HEK293 cultures dose-dependently at concentrations up to ∽ 100nM; however, its inhibitory effect is reversed through over-expression of Nox1, thereby suggesting that this compound is highly selective for Nox1, with little effect against Nox2-dependent ROS generation (IC 50 > 10μM)
- Qualitatively, it displays an inhibitory effect against SrcYF-induced ECM-degrading invadopodia formation in DLD1 Human Colon Cancer Cells.