70-451-00
Tocris Bioscience™ (+/-)-a-Lipoamide, Phase Separated
Manufacturer: Tocris Bioscience™
CAS Number: 940-69-2
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-451-00-Each-of-1 | In Stock | ₹ 11,459.64 |
70-451-00 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 11,459.64
GST (18%): ₹ 2,062.735
Total Price: ₹ 13,522.375
Chemical Name or Material
1,2-Dithiolane-3-pentanamide
Quantity
100 mg
Purity
98%
CAS
940-69-2
Molecular Formula
C8H15NOS2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Lipoamide | -- | ₹ 6,408.00 - ₹ 70,844.00 | ||
940-69-2 | Dl-5-(1,2-dithiolan-3-yl)valeramide | -- | ₹ 1,780.00 - ₹ 1,41,243.00 |
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Description
- (±)-α-Lipoamide is a phase-separated condensate modifier
- Reduces propensity of stress granule proteins to aggregate (EC50 = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro
- Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes
- Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D
- melanogaster expressing FUS mutants
- Suppresses the effects of ALS-associated FUS mutations in vivo in different systems
- Orally bioavailable.