7060025

MilliporeSigma™ Calbiochem™ 1-Aminocyclopropane-1-carboxylic Acid

An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

Manufacturer: Fischer Scientific

CAS Number: 22059-21-8

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Description

98% by TLC

CAS

22059-21-8

Formula Weight

101.1g/mol

Form

Crystalline Solid

Target Proteins

Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

Molecular Formula

C4H7NO2

Solubility

H2O

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Description

  • An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
  • Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3 H-glycine binding to rat forebrain membrane (IC 50 = 38 nM)
  • Blocks NMDA-induced release of arachidonic acid (IC 50 = 131μM) in cerebellar granule cells
  • Reduces NMDA-induced cell death in hippocampal neurons.