75-795-0
Tocris Bioscience™ Olaparib
Manufacturer: Fischer Scientific
CAS Number: 763113-22-0
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 75-795-0-Each-of-1 | In Stock | ₹ 38,893.00 |
75-795-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,893.00
GST (18%): ₹ 7,000.74
Total Price: ₹ 45,893.74
Chemical Name or Material
4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
Quantity
50 mg
Molecular Formula
C24H23FN4O3
CAS
763113-22-0
Target
Poly(ADP-ribose) Polymerase Inhibitors
Purity
0.98
Other Options
Related Products
Description
- Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively)
- Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates
- BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells
- Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat
- No
- 2706) in xenograft mouse model
- Olaparib is orally bioavailable in rats.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C