H1637
cis-4-Hydroxy-L-proline
collagen synthesis inhibitor
Manufacturer: Sigma Aldrich
CAS Number: 618-27-9
Synonym(S): (2S,4S)-(−)-4-Hydroxy-2-pyrrolidinecarboxylic acid, CHP
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | H1637-50-MG | In Stock | ₹ 7,620.80 |
| 250 MG | H1637-250-MG | In Stock | ₹ 20,697.40 |
| 1 G | H1637-1-G | In Stock | ₹ 68,673.80 |
H1637 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 7,620.80
GST (18%): ₹ 1,371.744
Total Price: ₹ 8,992.544
Quality Level
100
Assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white to faint yellow
mp
257 °C (dec.) (lit.)
application(s)
peptide synthesis
SMILES string
O[C@@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1
InChI key
PMMYEEVYMWASQN-IMJSIDKUSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Chem-Impex International, Inc. cis-L-4-Hydroxyproline | 618-27-9 | MFCD00064319 | 1G | -- | ₹ 6,236.23 | ||
cis-4-Hydroxy-L-proline | -- | ₹ 445.00 - ₹ 87,576.00 |
Related Products
Description
- Application: cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound.[1] CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells.[2] CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line[3] and rat pancreatic carcinoma cell line DSL6A.[4]
- Biochem/physiol Actions: cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.
- Other Notes: Constituent of Amanita sp. peptide toxins but not of animal proteins like collagen.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves