QBD10376

SPDP-dPEG®8-NHS ester

Manufacturer: Sigma Aldrich

CAS Number: 1252257-56-9

Select a Size

Pack Size SKU Availability Price
100 MG QBD10376-100-MG In Stock ₹ 24,074.80
1000 MG QBD10376-1000-MG In Stock ₹ 1,34,976.93

QBD10376 - 100 MG

₹ 24,074.80

In Stock

Quantity

1

Base Price: ₹ 24,074.80

GST (18%): ₹ 4,333.464

Total Price: ₹ 28,408.264

Assay

>90%

form

solid or viscous liquid

reaction suitability

reactivity: thiol reactivereagent type: cross-linking reagentreactivity: amine reactive

functional group

NHS ester

polymer architecture

shape: linearfunctionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCSSC2=NC=CC=C2

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Description

  • Features and Benefits: SPDP-dPEG®8-NHS ester has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Protein aggregation and precipitation also are greatly reduced with SPDP-dPEG crosslinkers compared to crosslinkers that have only hydrocarbon spacers. dPEG spacer of specific length (37.2 Å) provides precise distance control between the SPDP moiety and the target molecule. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using SPDP reagents.
  • Legal Information: Products Protected under U.S. Patents # 7,888,536 B2

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable