CDDO Methyl Ester
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 218600-53-4
Synonym(S): 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester, Bardoxolone Methyl, CDDO-Me
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 MG | SMB00376-10-MG | In Stock | ₹ 14,451.38 |
| 100 MG | SMB00376-100-MG | In Stock | ₹ 50,184.70 |
SMB00376 - 10 MG
In Stock
Quantity
1
Base Price: ₹ 14,451.38
GST (18%): ₹ 2,601.248
Total Price: ₹ 17,052.628
Quality Level
200
Assay
≥98% (HPLC)
form
powder
application(s)
metabolomicsvitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI
1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key
WPTTVJLTNAWYAO-KPOXMGGZSA-N
Gene Information
human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ CDDO-Me | -- | -- | ||
Selleck Chemical LLC Bardoxolone Methyl 25mg 218600-53-4 RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me | -- | ₹ 15,699.60 | ||
Medchemexpress LLC HY-13324 50mg Medchemexpress, Bardoxolone methyl CAS:218600-53-4 Purity:>98% | -- | ₹ 9,345.00 | ||
Sigma Aldrich Fine Chemicals Biosciences CDDO Methyl Ester >=98% (HPLC) | 218600-53-4 | MFCD11983137 | 100MG | -- | ₹ 57,244.80 | ||
Bardoxolone methyl | -- | ₹ 2,848.00 - ₹ 48,060.00 | ||
218600-53-4 | BARDOXOLONE METHYL | -- | ₹ 2,759.00 - ₹ 44,856.00 |
Description
- General description: CDDO-Me is a synthetic triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties.[1] It is derived from the natural product oleanic acid.[2]
- Application: CDDO Methyl Ester has been used to test its effect on hepatocyte membrane transporters (HMTs) regulation and mitigation of cholestasis in hepatic ischemia-reperfusion injury (IRI).[3] It has also been used activator of NF E2 Related Factor 2 (NRF2) to study its role in preventing cell death in melanoma cells.[4]
- Biochem/physiol Actions: CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents.[5] CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.[5]
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable