PEP0535
Invitrogen™ Human PTEN Synthetic Peptide
Manufacturer: Invitrogen™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PEP0535-Each-of-1 | In Stock | ₹ 16,901.10 |
PEP0535 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,901.10
GST (18%): ₹ 3,042.198
Total Price: ₹ 19,943.298
Gene ID (Entrez)
5728
Purification Method
purified
Common Name
Human PTEN
Content And Storage
-20°C
Format
Liquid
For Use With (Application)
Blocking Assay, Control
Gene Symbol
PTEN
Preservative
0.02% sodium azide
Quantity
50 μg
Storage Buffer
PBS
Species
Human
Accession Number
P60484
Concentration
200 μg/mL
Description
Synthetic Peptide
Formulation
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Gene Alias
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1, TEP1, Phosphatase and tensin homolog
Lyophilized
No
Product Type
Peptide
Regulatory Status
RUO - research use only
Related Products
Description
- PTEN Synthetic Peptide, PEP-0535, from Invitrogen
- PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency
- The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase
- It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases
- Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates
- PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway
- PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation
- Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue
- The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability
- PEP-0535 can be used as a blocking peptide with polyclonal antibody PA5-20418.