Invitrogen™ Mouse MECP2 (aa 469-486) Synthetic Peptide

Description

• Mouse MeCP2 (residues 469-486) Synthetic Peptide, PEP-121, from Invitrogen
• MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain
• MECP2 is capable of binding specifically to methylated DNA
• DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development
• MECP2 can also repress transcription from methylated gene promoters
• In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation
• MECP2 is dispensible in stem cells, but is essential for embryonic development
• MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females
• PEP-121 is a 18 amino acid synthetic peptide whose sequences are derived from amino acids 469-486 of mouse MeCP2 protein with a amino-terminal cysteine added for carrier protein conjugation
• The sequence of this peptide is (amino to carboxy terminus): C-P (469)-N-R-E-E-P-V-D-S-R-T-P-V-T-E-R-V-S (486)PEP-121 may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse MeCP2, catalog &Num PA1-888
• Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 mL of distilled water.