Description

• General description: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.It is an impurity of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol.[1]
• Application: This pharmaceutical secondary standard can also be used as follows:Separation and estimation of acetaminophen and its process impurities in commercial acetaminophen tablets using high-performance liquid chromatography (HPLC)[1]Development and validation of HPLC-based stability indicating method for the determination of acetaminophen, chlorpheniramine maleate, and their possible degradation products in an over-the-counter syrup formulation[2]Detection and quantification of paracetamol, phenylephrine hydrochloride, and paracetamol impurities in pharmaceutical formulations using four chemometric-based spectrophotometric methodsImpurity analysis of a combined suppository dosage form of paracetamol, codeine phosphate hemihydrate, and pitophenone hydrochloride using ion-pair reversed-phase liquid chromatography in combination with UV detection[3]Development of a thin-layer chromatography method combined with densitometry for the separation of acetaminophen and its related impurities from commercial dosage forms[4]
• Analysis Note: These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
• Other Notes: Values of analytes vary lot to lot.
• Footnote: To see an example of a Certificate of Analysis for this material enter LRAC0397 in the slot below. This is an example certificate only and may not be the lot that you receive.
• Recommended products: Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.