Methotrexate Related Compound B
United States Pharmacopeia (USP) Reference Standard
Manufacturer: Sigma Aldrich
CAS Number: 54-62-6
Synonym(S): Aminopterin, (S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 75 MG | 1414025-75-MG | In Stock | ₹ 1,59,873.30 |
1414025 - 75 MG
In Stock
Quantity
1
Base Price: ₹ 1,59,873.30
GST (18%): ₹ 28,777.194
Total Price: ₹ 1,88,650.494
grade
pharmaceutical primary standard
API family
methotrexate
manufacturer/tradename
USP
ε (extinction coefficient)
24,500 at 282 nm in 0.1 M NaOH at 1 M25,700 at 261 nm in 0.1 M NaOH at 1 M8,100 at 373 nm in 0.1 M NaOH at 1 M
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
InChI
1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
InChI key
TVZGACDUOSZQKY-LBPRGKRZSA-N
Other Options
Related Products
Description
- General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
- Application: Methotrexate Related Compound B USP reference standard for use in specified quality tests and assays.Additionally used to prepare standard, standard stock, system suitability, and system suitability stock solutions for impurity analysis in the given below monographs according to United States Pharmacopeia (USP):Methotrexate[1]Methotrexate Injection[2]Methotrexate for Injection[3]
- Biochem/physiol Actions: Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.
- Linkage: More potent, but more toxic, than methotrexate.
- Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
- Other Notes: Sales restrictions may apply.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P202 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
Hazard Classifications
Acute Tox. 1 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable