Peptidoglycan from Staphylococcus aureus

Description

• Application: Peptidoglycan from Staphylococcus aureus has been used:for the stimulation of lymphocytes: peptidoglycan activates the toll-like receptor 2 (TLR2), present in mammalian cells. It works as an antagonist of Poly (I:C)[1]for g-type lysozyme stimulation by intraperitoneally inoculating it into sole specimens[2]in phosphate buffer saline and injected into Labeo rohita fingerlings, to study its effect on nucleotide-binding oligomerization domain-2 (NOD-2) gene expression[3]
• Biochem/physiol Actions: The cell wall of gram positive bacteria is largely made up of peptidoglycan.[4] It is composed of polysaccharide chains interlinked by peptide bridges. This peptidoglycan gives a certain rigidity to the cell wall and gives the cell mechanical strength.[5] It is a surface molecule which is known to stimulate immune reactions including cytokine production to fever.[6]
• Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
• Other Notes: Major component of the cell wall in gram positive organisms. Consists of a glycan backbone with alternating β 1-4 linked residues of N-acetyl-D-glucosamine and muramic acid. The immunological activities of bacterial peptidoglycans[7]; Peptidoglycan types of bacterial cell walls and their taxonomic implications[8]; Antibody response to peptidoglycan during staphylococcal infections[9]