C6891
5-Chloro-2′-deoxyuridine
thymidine analog
Manufacturer: Sigma Aldrich
CAS Number: 50-90-8
Synonym(S): CldU
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | C6891-100-MG | In Stock | ₹ 10,695.10 |
C6891 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 10,695.10
GST (18%): ₹ 1,925.118
Total Price: ₹ 12,620.218
Quality Level
100
Assay
≥98% (HPLC)
form
powder
solubility
1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI
1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
NJCXGFKPQSFZIB-RRKCRQDMSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Sigma Aldrich Fine Chemicals Biosciences 5-Chloro-2′-deoxyuridine | 50-90-8 | MFCD00006531 | 100 mg | -- | ₹ 11,230.02 | ||
Medchemexpress LLC HY-112669 100mg Medchemexpress, 5-Chloro-2'-deoxyuridine 5-Chlorodeoxyuridine;CldU CAS:50-90-8 Purity:98% | -- | ₹ 7,476.00 | ||
5-Chloro-2'-deoxyuridine | -- | ₹ 4,984.00 - ₹ 67,373.00 | ||
50-90-8 | Uridine, 5-chloro-2'-deoxy- | -- | ₹ 3,204.00 - ₹ 73,603.00 |
Description
- Application: 5-Chloro-2′-deoxyuridine has been used to:study cell cycle dynamics by immunohistochemical analysis and double S-phase labeling using animal models[1]analyze cell cycle length using an animal model[2]label HEK293T cells for molecular combing assay[3]
- Biochem/physiol Actions: DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination.[4] CldU is a potent mutagen, clastogen, and toxicant.[5] It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest.[4] CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs.[5] 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves