Description

• General description: Carnosol (CAR) is an ortho-diphenolic diterpene, extracted from the Mediterranean dietary herb Rosmarinus officinalis L. (rosemary).[1] It was first isolated from the Salvia carnosa (Sage) plant.[1] Carnosol is also a pro-electrophilic molecule.[2]
• Application: Carnosol has been used as an anti-cancer agent:to test its anti-cancer and anti-proliferative activities on cancer stem-like cells (CSCs)[3] and Glioblastoma multiforme (GBM) cells[3][4]to inspect its anti-carcinogenic effects on nineteen genes involved in up-and down-regulation of different genetic carcinogenesis pathways and on HeLa cells in human cervical cancer model[5]as a reference standard to identify and quantify the metabolites of rosemary extract using liquid chromatography coupled to tandem mass spectrometry (LC/ESI-MS/MS)[6]
• Biochem/physiol Actions: Carnosol together with carnosic acid (CA) accounts for 90% of the antioxidant activity of rosemary leaves.[2] It exerts neuroprotective properties and protects against neuroinflammation[2], and oxidative stress-induced brain damage under chronic stress conditions.[7] Carnosol is a strong chemo-therapeutic agent studied for several types of cancer like breast, leukemia, skin, prostate, and colon.[1][8] It is also an antimicrobial agent.[9]