Dacarbazine
antineoplastic purine analog
Manufacturer: Sigma Aldrich
CAS Number: 4342-03-4
Synonym(S): 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide, DTIC
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 MG | D2390-100-MG | In Stock | ₹ 7,025.43 |
| 1 G | D2390-1-G | In Stock | ₹ 28,881.10 |
D2390 - 100 MG
In Stock
Quantity
1
Base Price: ₹ 7,025.43
GST (18%): ₹ 1,264.577
Total Price: ₹ 8,290.007
Quality Level
100
form
powder or crystals
solubility
1 M HCl: 50 mg/mL
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI
1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key
FDKXTQMXEQVLRF-ZHACJKMWSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Medchemexpress LLC HY-B0078 1g , Dacarbazine CAS:4342-03-4 Purity:>98% | -- | ₹ 12,335.40 | ||
eMolecules Ambeed / 5- (33-Dimethyl-1-triazenyl) imidazole-4-carboxamide / 50mg / 525197816 / A366851 / / 4342-03-4 / [null] / 182.187 / C6H10N6O | -- | ₹ 2,148.46 | ||
Dacarbazine Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | -- | ₹ 20,114.00 | ||
Sigma Aldrich Fine Chemicals Biosciences Dacarbazine British Pharmacopoeia (BP) Reference Standard | 4342-03-4 | MFCD00057167 | | -- | ₹ 28,455.97 | ||
Dacarbazine | -- | ₹ 18,976.23 | ||
Dacarbazine | -- | ₹ 33,330.18 | ||
Dacarbazine | -- | ₹ 14,267.35 | ||
Dacarbazine | -- | ₹ 19,062.83 |
Related Products
Description
- Application: Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.
- Biochem/physiol Actions: Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis.[1] It is known to induce hepatotoxicity in mice.[2] Dacarbazine is not cell cycle-phase specific.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves