D5011
5′-Deoxy-5′-(methylthio)adenosine
Manufacturer: Sigma Aldrich
CAS Number: 2457-80-9
Synonym(S): Methylthioadenosine, MTA
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 MG | D5011-25-MG | In Stock | ₹ 7,361.00 |
| 100 MG | D5011-100-MG | In Stock | ₹ 21,801.55 |
| 250 MG | D5011-250-MG | In Stock | ₹ 35,094.65 |
| 1 G | D5011-1-G | In Stock | ₹ 1,12,580.00 |
D5011 - 25 MG
In Stock
Quantity
1
Base Price: ₹ 7,361.00
GST (18%): ₹ 1,324.98
Total Price: ₹ 8,685.98
biological source
synthetic (organic)
Quality Level
200
Assay
≥98% (HPLC)
form
powder
solubility
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.
−20°C
SMILES string
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI
1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key
WUUGFSXJNOTRMR-IOSLPCCCSA-N
Gene Information
human ... ADORA2B(136) , ADORA3(140) mouse ... Mtap(66902) rat ... Adora1(29290) , Adora2a(25369)
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Sigma Aldrich Fine Chemicals Biosciences 5′-Deoxy-5′-(methylthio)adenosine | 2457-80-9 | MFCD00010533 | 25mg | -- | ₹ 8,401.60 | ||
Cayman Chemical 5'-Deoxy-5'-methylthioadenosine, 2457-80-9, 25 mg | -- | ₹ 4,521.20 | ||
Sigma Aldrich Fine Chemicals Biosciences 5′-Deoxy-5′-(methylthio)adenosine | 2457-80-9 | MFCD00010533 | 100 mg | -- | ₹ 24,967.17 | ||
eMolecules 5'-S-Methyl-5'-thioadenosine | 2457-80-9 | | 1g | -- | ₹ 22,926.40 | ||
5'-Methylthioadenosine | -- | ₹ 3,204.00 - ₹ 72,179.00 | ||
2457-80-9 | 5'-S-Methyl-5'-thioadenosine | -- | ₹ 3,204.00 - ₹ 69,153.00 |
Description
- Application: 5′-Deoxy-5′-(methylthio)adenosine has been used as a protein methylation inhibitor to reduce E2F transcription factor 1 (E2F1) protein abundance in hepatocellular carcinoma (HCC) cells.[1] It has also been used to inhibit histone methylation modification and study its role in hypoxia inducible factor-1 (Hif-1) nuclear transport.[2]
- Biochem/physiol Actions: 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves