D7145

2′-Deoxyguanosine monohydrate

99-100%

Manufacturer: Sigma Aldrich

CAS Number: 312693-72-4

Synonym(S): 2′-Deoxyguanosine hydrate, 9-(2-Deoxy-β-D-ribofuranosyl)guanine, Guanine-2′-deoxyriboside

Select a Size

Pack Size SKU Availability Price
25 MG D7145-25-MG In Stock ₹ 4,838.78
100 MG D7145-100-MG In Stock ₹ 11,203.88
1 G D7145-1-G In Stock ₹ 37,768.43
5 G D7145-5-G In Stock ₹ 1,36,384.18

D7145 - 25 MG

₹ 4,838.78

In Stock

Quantity

1

Base Price: ₹ 4,838.78

GST (18%): ₹ 870.98

Total Price: ₹ 5,709.76

biological source

synthetic (organic)

Quality Level

200

Assay

99-100%

form

powder

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

SMILES string

O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1

InChI

1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1

InChI key

LZSCQUCOIRGCEJ-FPKZOZHISA-N

Description

  • Application: 2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish[1],in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis[2],in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes[3]
  • Biochem/physiol Actions: Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s).[4] Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage.[5] This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.[6]

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable