70372

1,4-Naphthoquinone

purum, ≥96.5% (HPLC)

Manufacturer: Sigma Aldrich

CAS Number: 130-15-4

Synonym(S): α-Naphthoquinone

Select a Size

Pack Size SKU Availability Price
50 G 70372-50-G In Stock ₹ 3,399.05
250 G 70372-250-G In Stock ₹ 7,144.50
1 KG 70372-1-KG In Stock ₹ 16,486.48

70372 - 50 G

₹ 3,399.05

In Stock

Quantity

1

Base Price: ₹ 3,399.05

GST (18%): ₹ 611.829

Total Price: ₹ 4,010.879

grade

purum

Quality Level

200

Assay

≥96.5% (HPLC)

form

powder

mp

119-122 °C (lit.)120-124 °C

SMILES string

O=C1C=CC(=O)c2ccccc12

InChI

1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H

InChI key

FRASJONUBLZVQX-UHFFFAOYSA-N

Description

  • Application: 1,4-Naphthoquinone is the key structural moiety of many anticancer and antifungal agents.[1] It can be used to synthesize:[2]3,3-Disubstituted oxindoles via asymmetric Michael addition to oxindole. Bioactive isoindolines via asymmetric 1,3-dipolar cycloaddition to azomethine ylides generated in situ from aldehydes and diethyl aminomalonate. α,α-Difluoro-β-hydroxy ketone via ‘on water′ catalyst-free Mukaiyama-aldol reaction with difluoroenoxysilane. 2-Hydroxy-3-anilino-1,4-naphthoquinone, which shows potent in vivo antimalarial activity. Additional appilcation include:[2] As an arylation reagent for the α-arylation of aldehydes. As a starting material in the multi-step synthesis of benz[f]indole-4,9-diones.

SAFETY INFORMATION

Pictograms

GHS06,GHS05,GHS09

Signal Word

Danger

Hazard Statements

H301,H314,H317,H330,H335,H410

Precautionary Statements

P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

285.8 °F

Flash Point(C)

141 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves