Description

• General description: Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions.[1]
• Application: Chlorotrimethylsilane (TMSCl) can be used as:        A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines.[2][3]       A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents.[3]         A trapping agent for the anions generated during acyloin condensation reaction.[4]        A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols.[5] A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters.[6]         A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides.[7]        A reagent in Fischer glycosidation.[8]        A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et3SiH.[9]A reagent to synthesize sodium trimethylsilanethiolate (Me3SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me3SiSNa from foul-smelling bis(trimethylsilyl)sulfide and sodium methoxide.[10]