200007272
Tocris Bioscience™ ARN 3236
Potent inhibitor of salt-inducible kinases
Manufacturer: Fischer Scientific
CAS Number: 1613710-01-2
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Chemical Name or Material
3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1 H-pyrrolo[2,3-b]pyridine
Target
SNF1LK2/SIK2
Purity
0.98
CAS
1613710-01-2
Molecular Formula
C19H16N2O2S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ ARN 3236 | -- | ₹ 11,025.32 | ||
Tocris Bioscience™ ARN 3236 | -- | ₹ 46,363.66 | ||
1613710-01-2 | 3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine | -- | ₹ 1,602.00 - ₹ 1,60,645.00 |
Related Products
Description
- ARN 3236 is a potent of salt-inducible kinase 2 (SIK2) inhibitor (IC50 values are <1 nM, 6.63 nM and 21.63 nM for SIK2, SIK3 and SIK1 respectively)
- ARN 3236 inhibits centrosome separation by uncoupling the centrosome from the nucleus
- It also induces cell-cycle arrest and apoptosis by attenuating the AKT/survivin pathway
- ARN 3236 inhibits growth and enhances Taxol (Cat
- No
- 1097) sensitivity in ovarian cancer cell lines in vitro and in vivo
- In human myeloid cells, ARN 3236 blocks TNF and induces IL-10 upon LPS stimulation; it also reduces the production of IL-1β upon activation of TLR4 and TLR2 signaling
- In depression models, ARN 3236 exhibits antidepressant-like effects via the hippocampal CRTC1-CREB-BDNF pathway
- ARN 3236 penetrates the blood-brain barrier, and it is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C