200009228
Tocris Bioscience™ Belinostat
Potent pan-HDAC inhibitor
Manufacturer: Fischer Scientific
CAS Number: 866323-14-0
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Chemical Name or Material
(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
Target
Histone Deacetylase Inhibitors
Purity
98%
CAS
866323-14-0
Molecular Formula
C15H14N2O4S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ Belinostat | -- | ₹ 7,520.50 | ||
Tocris Bioscience™ Belinostat | -- | ₹ 31,906.50 | ||
Medchemexpress LLC HY-10225 200mg , Belinostat CAS:866323-14-0 Purity:>98% | -- | ₹ 39,249.00 | ||
eMolecules N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE | 866323-14-0 | MFCD08064035 | 1g | -- | ₹ 14,935.09 | ||
866323-14-0 | Belinostat | -- | ₹ 4,005.00 - ₹ 1,17,035.00 |
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Description
- Belinostat is a potent pan-HDAC inhibitor (IC50 = 28 nM)
- Dose-dependently reduces tumor volume in a rat model of glioblastoma and induces 70% and 28% apoptosis in LN-229 and LN-18 glioma cell lines (IC50 values are 210 nM and 300 nM respectively)
- In H358 cells, Belinostat dose-dependently reduces cell viability and upregulates amino acids and metabolites of the TCA and urea cycle
- Also potently inhibits C4 release from stem cell-derived astrocytes and shows antidepressant activity
- Belinostat is brain penetrant.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C