60-531-0
Tocris Bioscience™ LDN 193189 dihydrochloride
Manufacturer: Fischer Scientific
CAS Number: 1435934-00-1
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 60-531-0-Each-of-1 | In Stock | ₹ 29,192.00 |
60-531-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 29,192.00
GST (18%): ₹ 5,254.56
Total Price: ₹ 34,446.56
Chemical Name or Material
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Synonym
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Solubility
Soluble to 50mM in water and to 20mM in DMSO
Molecular Formula
C25H22N60.2 HCl
Physical Form
Solid
Product Type
Bioactive Small Molecule
CAS
1435934-00-1
Quantity
10 mg
Target
BMP and Other Activin Receptor Inhibitors
Formula Weight
479.4
Color
Orange
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ LDN 193189 dihydrochloride | -- | -- | ||
Tocris Bioscience™ LDN 193189 dihydrochloride | -- | ₹ 1,10,360.00 | ||
1435934-00-1 | LDN 193189 hydrochloride | -- | ₹ 2,047.00 - ₹ 17,622.00 |
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Description
- LDN 193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation
- Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling
- Also exhibits selectivity over AMPK, PDGFR and MAPK signaling
- Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No
- 1614)
- Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No
- 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No
- 4423) and DAPT (Cat.No
- 2634)
- LDN 193189 synthesized to Ancillary Material Grade also available
- For more information about how LDN 193189 dihydrochloride may be used, see our protocols: Generation of β cells from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Accelerated Induction of Cortical Neurons from hiPSCs .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C