65-771-0
Tocris™ Pyridone 6
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 65-771-0-Each-of-1 | In Stock | ₹ 25,142.50 |
65-771-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,142.50
GST (18%): ₹ 4,525.65
Total Price: ₹ 29,668.15
Synonym
JAK inhibitor I
Molecular Formula
C18H16FN3O
Product Type
Inhibitor
Quantity
10 mg
Formula Weight
309.34
Purity
98%
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Description
- Pyridone 6 is a potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50 values are 1, 5, 15 and 1 nM, respectively)
- Inhibits other kinases tested at 130 nM to >10 μM
- Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation
- Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells
- When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs
- Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells
- Cell-permeable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C