69-345-0
Tocris™ 673 A
Manufacturer: Fischer Scientific
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Quantity
50 mg
Formula Weight
223.28
Purity
98%
Molecular Formula
C15H13NO
Product Type
Inhibitor
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Description
- 673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively)
- Exhibits >40-fold selectivity for ALD1A over ALDH2
- Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines
- Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP)
- Overcomes chemotherapy resistance in vivo .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C