69-815-0
Tocris Bioscience™ TL 0259
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 69-815-0-Each-of-1 | In Stock | ₹ 1,40,976.00 |
69-815-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,40,976.00
GST (18%): ₹ 25,375.68
Total Price: ₹ 1,66,351.68
Chemical Name or Material
3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride
Quantity
50 mg
Molecular Formula
C32H34F3N5O4.2HCl
Purity
98%
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Description
- TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively)
- Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases
- Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro
- Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts
- Orally bioavailable.