7082174

Tocris Bioscience™ JTE 607 Dihydrochloride

Cytokine release inhibitor; anti-inflammatory

Manufacturer: Fischer Scientific

CAS Number: 188791-09-5

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Chemical Name or Material

JTE 607 dihydrochloride

Synonym

N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

Molecular Formula

C25H31Cl2N3O5·2HCl

Physical Form

Solid

Purity

>98%

CAS

188791-09-5

Solubility

Soluble to 100mM in water and to 100mM in DMSO

Formula Weight

597.36

Product Type

Bioactive Small Molecule

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Description

  • Cytokine release inhibitor
  • Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs
  • Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model
  • Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.

SAFETY INFORMATION

  • Recommended Storage : Desiccate at Room Temperature