7110969
Tocris Bioscience™ GNF 7
Ras signaling inhibitor; inhibits Ack1 and GCK
Manufacturer: Fischer Scientific
CAS Number: 839706-07-9
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Chemical Name or Material
Ras GTPase Inhibitors
Target
Small G Protein Inhibitors
Formula Weight
547.53
CAS
839706-07-9
Molecular Formula
C28H24F3N7O2
Purity
>98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ GNF 7 | -- | ₹ 22,093.36 | ||
Tocris Bioscience™ GNF 7 | -- | ₹ 92,193.32 | ||
Medchemexpress LLC HY-10943 5mg Medchemexpress, GNF-7 CAS:839706-07-9 Purity:>98% | -- | ₹ 10,092.60 | ||
eMolecules Medchem Express / GNF-7 / 5mg / 446259574 / HY-10943 / / 839706-07-9 / MFCD18251569 / 547.542 / C28H24F3N7O2 | -- | ₹ 14,149.22 | ||
839706-07-9 | BenzaMide, N-[3-[1,4-dihydro-1-Methyl-7-[(6-Methyl-3-pyridinyl)aMino]-2-oxopyriMido[4,5-d]pyriMidin-3(2H)-yl]-4-Methylphenyl]-3-(trifluoroMethyl)- | -- | ₹ 2,581.00 - ₹ 14,418.00 |
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Description
- GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T
- GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK)
- GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells
- It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C