7121028
Tocris Bioscience™ FRAX 597
Potent group I PAK inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1286739-19-2
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Chemical Name or Material
FRAX 597
Synonym
6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Target
PAK Inhibitors
Formula Weight
558.1
Color
Yellow
Purity
>98%
CAS
1286739-19-2
Solubility
Soluble to 20mM in DMSO
Molecular Formula
C29H28ClN7OS
Physical Form
Solid
Product Type
Bioactive Small Molecule
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ FRAX 597 | -- | ₹ 30,260.00 | ||
Tocris Bioscience™ FRAX 597 | -- | ₹ 1,26,736.00 | ||
Selleck Chemical LLC FRAX597 5mg 1286739-19-2 | -- | ₹ 21,039.60 | ||
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]- | -- | ₹ 2,047.00 - ₹ 13,528.00 |
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Description
- Potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively)
- Exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4)
- Inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C