7121041
Tocris Bioscience™ PF 06409577
Potent and selective allosteric activator of AMPK
Manufacturer: Fischer Scientific
CAS Number: 1467057-23-3
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Chemical Name or Material
PF 06409577
Synonym
6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
Molecular Formula
C19H16ClNO3
Physical Form
Solid
Product Type
Bioactive Small Molecule
CAS
1467057-23-3
Solubility
Soluble to 100mM in DMSO and to 20mM in ethanol
Formula Weight
341.79
Color
Gray
Purity
99%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ PF 06409577 | -- | ₹ 95,586.00 | ||
Tocris Bioscience™ PF 06409577 | -- | ₹ 23,807.50 | ||
Sigma Aldrich Fine Chemicals Biosciences PF-06409577 | 1467057-23-3 | MFCD29917835 | 25mg | -- | ₹ 47,739.60 | ||
1H-Indole-3-carboxylic acid, 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]- | -- | ₹ 979.00 - ₹ 35,867.00 |
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Description
- Potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively)
- Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases
- Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at Room Temperature