7161607

Tocris Bioscience™ BMH 21

RNA polymerase I inhibitor; also p53 pathway activator

Manufacturer: Fischer Scientific

CAS Number: 896705-16-1

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Chemical Name or Material

N-[2-(Dimethylamino)ethyl]-12-oxo-12 H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

Target

RNA/DNA Polymerase Inhibitors

Formula Weight

360.41

CAS

896705-16-1

Molecular Formula

C21H20N4O2

Purity

98%

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Description

  • p53 pathway activator; induces expression of p53 target genes
  • Also RNA polymerase 1 inhibitor; promotes degradation of RPA194
  • Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C