7166776
Tocris™ VU 0650991
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
Manufacturer: Fischer Scientific
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Molecular Formula
C16H11ClF6N4O2
Formula Weight
440.73
Product Type
Antagonist
Purity
98%
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Description
- VU 0650991 is a noncompetitive glucagon-like peptide-1 (GLP-1) receptor antagonist (IC50 = 0.65 - 0.69 μM)
- Displays >40-fold selectivity for GLP-1 receptor over glucagon receptors
- Blocks activity of Exendin-4 (Cat
- No
- 1933) in potentiating insulin secretion from primary mouse pancreatic islets in vitro
- Decreases blood insulin and increases blood glucose levels in vivo
- Brain penetrant and orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C