7166833
Tocris™ Galunisertib
ALK4 and ALK5 (TGFβRI) inhibitor
Manufacturer: Fischer Scientific
CAS Number: 700874-72-2
The price for this product is unavailable. Please request a quote
Chemical Name or Material
4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
Target
TGF-beta Receptor Inhibitors
Formula Weight
369.43
Purity
98%
CAS
700874-72-2
Molecular Formula
C22H19N5O
Product Type
Inhibitor
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris™ Galunisertib | -- | ₹ 14,702.80 | ||
Tocris™ Galunisertib | -- | ₹ 55,714.00 | ||
Medchemexpress LLC HY-13226 100mg , Galunisertib CAS:700874-72-2 Purity:>98% | -- | ₹ 23,362.50 | ||
Medchemexpress LLC HY-13226 50mg , Galunisertib CAS:700874-72-2 Purity:>98% | -- | ₹ 14,017.50 | ||
Medchemexpress LLC HY-13226 10mg Medchemexpress, Galunisertib CAS:700874-72-2 Purity:>98% | -- | ₹ 6,541.50 | ||
eMolecules 4-(2-(6-METHYLPYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL-3-YL)QUINOLINE-6-CARBOXAMIDE | 700874-72-2 | 1G | Purity: 95% | -- | ₹ 1,27,207.70 | ||
Cayman Chemical LY2157299, 700874-72-2, 10 mg | -- | ₹ 31,728.50 | ||
Selleck Chemical LLC Galunisertib (LY2157299) 5mg 700874-72-2 | -- | ₹ 18,156.00 | ||
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide | -- | ₹ 979.00 - ₹ 92,471.00 |
Related Products
Description
- ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively)
- Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B
- Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo
- Also reverses TGFβ-mediated suppression of T cell proliferation
- Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo
- Used as component of growth media for urothelial organoids
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C