72-401
Tocris Bioscience™ ZNL 02-096
Manufacturer: Tocris Bioscience™
CAS Number: 2414418-49-6
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 72-401-Each-of-1 | In Stock | ₹ 46,413.50 |
72-401 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Chemical Name or Material
4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1 H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Quantity
1 mg
Molecular Formula
C42H45N11O6
CAS
2414418-49-6
Target
Active Degraders
Purity
0.98
Related Products
Description
- ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC™) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat
- No
- 6302)
- ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target
- In MOLT-4 cells in vitro , ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis
- The compound shows antiproliferative effects in a panel of 300 cancer cell lines
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C