7235739
Tocris™ Takinib
Potent and selective TAK1/MAP3K7 kinase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1111556-37-6
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Chemical Name or Material
N1-(1-Propyl-1 H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
Target
Other Kinase Inhibitors
Purity
0.98
CAS
1111556-37-6
Molecular Formula
C18H18N4O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris™ Takinib | -- | ₹ 41,207.00 | ||
Tocris™ Takinib | -- | ₹ 10,012.50 | ||
1111556-37-6 | Takinib | -- | ₹ 2,581.00 - ₹ 91,047.00 |
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Description
- Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC50 = 8.2-9.5 nM)
- Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC50 values = 120, 390, 430, 430 and 1900 nM, respectively)
- Demonstrates weak inhibition at Src and Yes1
- Exhibits no inhibition of MAP2K or other MAP3K family members
- Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C