7237097
Tocris Bioscience™ NS 383
ASIC blocker; active in vivo
Manufacturer: Fischer Scientific
CAS Number: 309711-59-9
The price for this product is unavailable. Please request a quote
Chemical Name or Material
8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1 H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
CAS
309711-59-9
Target
Acid-sensing Ion Channel Blockers
Molecular Formula
C19H19N3O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ NS 383 | -- | ₹ 16,105.44 | ||
Tocris Bioscience™ NS 383 | -- | ₹ 67,106.00 |
Related Products
Description
- NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3)
- Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3)
- Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C