7237102

Tocris Bioscience™ Santacruzamate A

Highly potent and selective HDAC2 inhibitor

Manufacturer: Fischer Scientific

CAS Number: 1477949-42-0

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Chemical Name or Material

Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate

Target

Class II Histone Deacetylases Inhibitors

Purity

0.98

CAS

1477949-42-0

Molecular Formula

C15H22N2O3

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Description

  • Santacruzamate A is a highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC50 = 112 - 119 pM)
  • Also inhibits HDAC6 in nanomolar range (IC50 = 433 nM)
  • Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC50 >1 μM for HDAC4)
  • Inhibits growth of HuT-78 cutaneous T-cell lymphoma cell line
  • Identified as targeting human host proteins that interact with SARS-CoV-2.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C