7239453
Tocris Bioscience™ Adavosertib
Potent and selective Wee1 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 955365-80-7
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Chemical Name or Material
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
Target
Checkpoint Control Kinase Inhibitors
Purity
98%
CAS
955365-80-7
Molecular Formula
C27H32N8O2
Other Options
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Description
- Adavosertib is a potent and selective Wee1 inhibitor (IC50 = 5.2 nM)
- In a panel of 223 serine/threonine or tyrosine kinases, Adavosertib is highly selective for Wee 1 over all except 8 kinases
- In particular Adavosertib shows >100-fold selectivity over human Myt1
- Adavosertib blocks CDC2Y15 phosphorylation and Gemcitabine (Cat
- No
- 3259)-induced DNA damage checkpoint, leading to premature mitotic entry and apoptosis in p53-deficient tumor cell lines
- Adavosertib also potentiates the cytotoxic effects of Pemetrexed (Cat
- No
- 6185), Doxorubicin (Cat
- No
- 2252), Camptothecin (Cat
- No
- 1100) and Mitomycin C (Cat
- No
- 3258) in vitro
- Adavosertib synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C