7249496
Tocris Bioscience™ AZD 4547
Potent and selective FGFR inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1035270-39-3
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Chemical Name or Material
rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
CAS
1035270-39-3
Target
FGF Receptor Inhibitors
Molecular Formula
C26H33N5O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ AZD 4547 | -- | ₹ 23,273.50 | ||
Tocris Bioscience™ AZD 4547 | -- | -- | ||
Medchemexpress LLC HY-13330 50mg , AZD4547 CAS:1035270-39-3 Purity:>98% | -- | ₹ 17,288.25 | ||
Biotang Inc AZD4547, Free Base, > 99%, 50MG, M.W. 463.57, C26H33N5O3, CAS#1035270-39-3. | -- | ₹ 25,979.10 | ||
Selleck Chemical LLC AZD4547 10mg 1035270-39-3 | -- | ₹ 21,039.60 | ||
eMolecules Ambeed / rel-N-(5-(35-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R5S)-35-dimethylpiperazin-1-yl)benzamide / 1mg / 713090386 / A868383 / / 1035270-39-3 / MFCD22580423 / 463.582 / C26H33N5O3 | -- | ₹ 2,148.46 | ||
Medchemexpress LLC HY-13330 10mg Medchemexpress, AZD4547 CAS:1035270-39-3 Purity:>98% | -- | ₹ 8,597.40 |
Related Products
Description
- AZD 4547 is a potent and selective FGFR1, FGFR3 and FGFR2 tyrosine kinase inhibitor (IC50 values are 0.2 1.8, and 2.5 nM, respectively)
- It shows selectivity for FGFR across a range of unrelated tyrosine and serine/threonine kinases, including IGFR (>2,900-fold), CDK2 (>50,000-fold), and p38 (>50,000-fold)
- In vitro , it has antiproliferative effects on tumor cell lines with deregulated FGFR expression
- In vivo , AZD 4547 exhibits dose-dependent inhibition of tumor growth in an FGFR-driven human tumor xenograft mice model
- It suppresses osteoclastogenesis and tumor-induced osteolysis in an orthotopic breast cancer bone metastasis mouse model
- AZD 4547 is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.