73-751-0
Tocris Bioscience™ RO 8191
Manufacturer: Tocris Bioscience™
CAS Number: 691868-88-9
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Chemical Name or Material
8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8 ]naphthyridine
Quantity
10 mg
Molecular Formula
C14H5F6N5O
CAS
691868-88-9
Target
IFN-alpha/beta R2
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
eMolecules Medchem Express / RO8191 / 5mg / 572597148 / HY-W063968 / / 691868-88-9 / MFCD03102493 / 373.218 / C14H5F6N5O | -- | ₹ 14,410.88 | ||
8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE | -- | ₹ 4,183.00 - ₹ 7,120.00 | ||
691868-88-9 | 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE | -- | ₹ 2,581.00 - ₹ 93,183.00 |
Related Products
Description
- RO 8191 is an IFNα receptor 2 (IFNAR2) agonist (EC50 = 0.2 μM)
- RO 8191 induces phosphorylation and activation of STAT1 and STAT2
- RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC50 values 0.20 μM and 0.17 μM, respectively) and inhibits hepatitis B virus replication in cell cultures (IC50 = 0.1 μM)
- In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin β6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C