74-571-0
Tocris Bioscience™ CAM 833
Manufacturer: Tocris Bioscience™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 74-571-0-Each-of-1 | In Stock | ₹ 31,506.00 |
74-571-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,506.00
GST (18%): ₹ 5,671.08
Total Price: ₹ 37,177.08
Chemical Name or Material
N-(2-((2 S,4 R)-2-((-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
Target
DNA, RNA and Protein Synthesis Compounds
Purity
0.98
Quantity
10 mg
Molecular Formula
C26H26ClFN4O5
Related Products
Description
- CAM 833 a selective orthosteric inhibitor of the BRCA2-RAD51 interaction (Kd of 366 nM; IC50 of 6 μM)
- CAM 833 has no significant off-target interactions when screened at 10 μM in the Cerep ExpresSPanel
- It inhibits DNA recombinase RAD51-mediated homologous recombination through binding to RAD51 at the same site as the BRCA2 FxxA motif
- In cells, CAM 833 suppresses the assembly of RAD51 into damage-induced filaments at the sites of DNA damage
- CAM 833 potentiates radiation-induced cytotoxicity and poly-ADP ribose polymerase (PARP)1 inhibitor- induced growth suppression in BRCA2-wild-type cells
- The product is metabolically stable, does not significantly inhibit CYP450 enzymes, and is suitable for in vivo investigation.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C