75-721-0
Tocris Bioscience™ NR 162
Manufacturer: Tocris Bioscience™
CAS Number: 2755241-73-5
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Chemical Name or Material
4-(Cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide
Quantity
10 mg
Molecular Formula
C24H30Br2N6O3
CAS
2755241-73-5
Target
CaM Kinase Inhibitors
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
2755241-73-5 | CASK-IN-1 | -- | -- |
Related Products
Description
- NR 162 is a potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor (IC50 = 80 nM); it exhibits no significant activity against related kinases MERTK, AXL and ABL1 and ~ 47-fold selectivity over TYRO3 (IC50 = 3.8 μM)
- NR 162 targets the unique pocket created by CASK GFG motif; it is a type-I inhibitor which stabilizes the active state of CASK without affecting the scaffolding function
- NR 162 induces cell death in actively differentiating cells of the P19 neuronal differentiation model
- NR 162 shows no toxicity in differentiated cells, or in cancer cells.
SAFETY INFORMATION
- Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.