78-165
Tocris Bioscience™ UNC 6852
Manufacturer: Tocris Bioscience™
CAS Number: 2688842-08-0
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 78-165-Each-of-1 | In Stock | ₹ 20,470.00 |
78-165 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,470.00
GST (18%): ₹ 3,684.60
Total Price: ₹ 24,154.60
Chemical Name or Material
(2 S,4 R)-1-(-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4 ]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Quantity
5 mg
Molecular Formula
C43H48N10O6S
CAS
2688842-08-0
Target
Active Degraders
Purity
0.98
Related Products
Description
- UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC™; DC50 = 0.79 μM)
- It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand
- In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC50 = 0.31 μM, Dmax = 94%), enhancer of zeste homolog 2 (EZH2, DC50 = 0.67 μM, Dmax = 96%), and suppressor of zeste homolog 12 (SUZ12, DC50 = 0.59 μM, Dmax = 82%)
- In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury
- PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C