79-045-0
Tocris Bioscience™ RU.521
Manufacturer: Fischer Scientific
CAS Number: 2262452-06-0
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 79-045-0-Each-of-1 | In Stock | ₹ 93,183.00 |
79-045-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 93,183.00
GST (18%): ₹ 16,772.94
Total Price: ₹ 1,09,955.94
Chemical Name or Material
3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Quantity
50 mg
Molecular Formula
C19H12Cl2N4O3
CAS
2262452-06-0
Target
Synthase/Synthetase Inhibitors
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ RU.521 | -- | -- | ||
Tocris Bioscience™ RU.521 | -- | ₹ 22,294.50 | ||
Medchemexpress LLC HY-114180 50mg , RU.521 CAS:2262452-06-0 Purity:>98% | -- | ₹ 45,790.50 |
Related Products
Description
- RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 μM and 2.94 μM against m-cGAS and h-cGAS, respectively)
- RU.521 suppresses dsDNA-activated reporter activity but not 5'ppp-HP20 RNA or murine IFN-β-induced IFN-β1-dependent gene expression
- RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Gouti?res syndrome
- Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C