38-211-310MG
MilliporeSigma™ Calbiochem™ Histone Acetyltransferase p300 Inhibitor, C646
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 38-211-310MG-Each-of-1 | In Stock | ₹ 13,904.47 |
38-211-310MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 13,904.47
GST (18%): ₹ 2,502.805
Total Price: ₹ 16,407.275
Color
Brick Red
Molecular Formula
C24H19N3O6
Solubility
DMSO
Form
Solid
Description
99% by HPLC (sum of isomers)
Formula Weight
445.42g/mol
Content And Storage
Protect from light
Quantity
10 mg
Related Products
Description
- A reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (K i = 400nM), which competes with acetyl-CoA for the p300 Lys-CoA binding pocket
- This compound demonstrates 86% inhibition against p300 at 10 nM, but elicits less than 10% inhibition against serotonin N-acetyltransferase, PCAF histone acetyltransferase, GCN5 histone acetyletransferase, Rtt109 histone acetyletransferase, Sas histone acetyl transferase, and MOZ histone acetyltransferase in a chemical screening assay
- Treatment of C3H 10T1/2 mouse fibroblasts with 25μM of compound results in an inhibitory effect against basal and TSA-inducible acetylation of histones H3 and H4
- It is also shown to inhibit human cell growth in both melanoma and non-small-cell-lung (NSCL) cancer cell lines at 10μM with similar or higher potency compared with that of the peptide-based bisubstrate p300/CBP HAT inhibitor Lys-CoA-Tat at 25μM.