38-219-1500UG
MilliporeSigma™ Calbiochem™ HMTase Inhibitor II, Chaetocin
Manufacturer: MilliporeSigma™
CAS Number: 28097-03-2
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 38-219-1500UG-Each-of-1 | In Stock | ₹ 21,569.15 |
38-219-1500UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 21,569.15
GST (18%): ₹ 3,882.447
Total Price: ₹ 25,451.597
Color
White
CAS
28097-03-2
Formula Weight
696.9g/mol
Content And Storage
Protect from light
Quantity
500 μg
Description
97% by HPLC
Molecular Formula
C30H28N6O6S4
Solubility
DMSO or CHCl3
Form
Solid
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Medchemexpress LLC HY-N2019 5mg , Chaetocin CAS:28097-03-2 Purity:>98% | -- | ₹ 45,790.50 | ||
Medchemexpress LLC HY-N2019 1mg Medchemexpress, Chaetocin CAS:28097-03-2 Purity:>98% | -- | ₹ 14,952.00 | ||
28097-03-2 | Chaetocin | -- | ₹ 13,439.00 - ₹ 84,639.00 |
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Description
- A naturally occurring cell-permeable Chaetomium fungal epi-dithio-diketopiperazine that potently inhibits the H3K9 histone methyltransferase activity of Drosophila melanogaster SU(VAR)3-9 and its human homologue SUV39H1 (IC 50 = 600 and 800 nM, respectively) in a SAM-competitive manner, while exhibiting much reduced potency against murine G9a or Neurospora crassa DIM5 H3K9 HMT (IC 50 = 2.5 and 3μM, respectively) and no activity against the H3K27 HMTase activity of Drosophila E(z), the H3K4 activity of bacterial SET7/9, or the H4K20 activity of bacterial PRSET7
- Although the reduction of intramolecular disulfide bonds of Chaetocin does not affect its HMTase inhibitory activity in cell-free enzymatic assays, the integrity of the disulfide bonds is shown to be essential for its cellular uptake
- Myeloma cell lines as well as myeloma cells isolated from patients are shown to be especially susceptible to death upon H 2 O 2 or Chaetocin treatment due to their heightened sensitivity to cellular oxidative stress induced by these agents.