61-646-75MG
MilliporeSigma™ Calbiochem™ Transglutaminase 2 Inhibitor, ZDON
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 61-646-75MG-Each-of-1 | In Stock | ₹ 26,657.28 |
61-646-75MG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,657.28
GST (18%): ₹ 4,798.31
Total Price: ₹ 31,455.59
Color
Off-white
Molecular Formula
C31H45N7O9
Form
Powder
Description
98% by HPLC
Solubility
DMSO
Quantity
5 mg
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Description
- A cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC 50 = 150nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2
- Exhibits far less potency against TG1 and TG3
- Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (∽50 mM)
- Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells
- Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.