7060174

MilliporeSigma™ Calbiochem™ Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride

Inhibits trypsin-like serine proteinases.

Manufacturer: Fischer Scientific

CAS Number: 4238-41-9

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Color

Off-white

Target Proteins

trypsin like proteases

Molecular Formula

C14H21ClN2O3S·HCl

Solubility

Aqueous solutions (unstable above pH 6.0)

Form

Solid

Description

95% by elemental analysis

CAS

4238-41-9

Formula Weight

369.3g/mol

Content And Storage

Hygroscopic

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Description

  • Inhibits trypsin-like serine proteinases
  • Irreversibly inactivates trypsin without affecting chymotrypsin
  • Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene
  • Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells
  • In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC 50 = 80μM)
  • Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.