Description

• Aprotinin is found in bovine lymph nodes, lung, parotid gland, spleen, liver, pancreas, seminal vesicles, thyroid gland, kidney, mucous membranes of the trachea and esophagus, ovaries, heart, posterior pituitary and cartilage
• It is reactive against trypsin, chymotrypsin, plasmatic and glandular kininogenases, plasmin, kallkrein, urokinase, clotting factor XIIa, protein C, proteinases of the complement system, and leukocyte and tissue proteinases
• It does not inhibit thrombin
• Uses include: Small amounts can be added to tubes of drawn blood to enable laboratory measurement of rapidly degraded proteins, such as glucagon
• Can be labelled with fluorescein isothiocyanate for use as a fluorescent histochemical reagent for staining glycoconjugates (mucosubstances) that are rich in uronic or sialic acids
• The conjugate retains its antiproteolytic and carbohydrate-binding properties
• Used in cell biology as an enzyme inhibitor to prevent protein degradation during lysis or homogenization of cells and tissues.